• Reduces stomach acid to treat heartburn and ulcers
  • Provides an effective alternative when PPIs are unsuitable
  • A different mode of action from famotidine-based treatments

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Overview

When frequent heartburn and acid reflux keep interfering with daily life, Nizatidine provides reliable relief by tackling stomach acid at its source. As a trusted H2 blocker, Nizatidine helps reduce excess acid, soothe irritation, and prevent painful flare-ups. Taken once or twice daily, it works to protect your oesophagus and restore comfort, so you can enjoy meals and sleep without the constant worry of reflux symptoms.

At SwiftMedi, every request for Nizatidine is carefully reviewed by a UK-registered prescriber through a secure online consultation, with discreet delivery straight to your door.


What is Nizatidine


Nizatidine is part of the group of medicines known as H2 receptor antagonists (H2RAs). It works by blocking the histamine-2 receptors in the stomach lining, which are responsible for triggering acid production. By reducing stomach acid levels, it helps relieve discomfort while allowing the oesophagus and stomach lining to heal.

Nizatidine is prescribed for heartburn and acid reflux, gastro-oesophageal reflux disease (GORD), and for the treatment and prevention of stomach or duodenal ulcers. It is also used in conditions where the stomach produces too much acid, such as Zollinger–Ellison syndrome.

It may be chosen as an alternative to other H2RAs (such as famotidine) or when proton pump inhibitors (PPIs) are not suitable, offering another trusted option for acid control.

Directions

  • Usual adult dose: 150mg twice daily or 300mg once daily, depending on your condition.
  • Can be taken with or without food.
  • Swallow capsules whole with water.
  • Treatment duration varies — typically a few weeks for ulcers or longer for reflux.


Always follow the instructions from your prescriber.

Side Effects

Like all medicines, nizatidine can cause side effects, although not everyone will experience them. Most are mild, short-lived, and improve as your body adjusts to treatment.

Common (may affect up to 1 in 10 people):

  • Headache – usually mild and temporary.
  • Diarrhoea or constipation – digestive changes are generally mild and short-lived.
  • Dizziness – may affect alertness; avoid driving or operating machinery if you feel unwell.


Uncommon (may affect up to 1 in 100 people):

  • Rash or itching – mild skin reactions may occur.
  • Sleep disturbances – difficulty sleeping or vivid dreams have been reported in some cases.
  • Muscle or joint pain – typically mild but should be monitored if persistent.


Rare but serious (seek urgent medical advice):

  • Severe allergic reaction (anaphylaxis) – symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, or a sudden rash.
  • Liver problems – yellowing of the skin or eyes (jaundice), dark urine, or ongoing tiredness may be signs of liver issues.
  • Mood changes or confusion – more likely in older patients; stop treatment and seek medical help if this occurs.


Most people tolerate nizatidine well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Nizatidine may not be suitable if you:

  • Are allergic to Nizatidine or other H2 blockers
  • Have kidney or liver problems — dose adjustments may be needed
  • Are taking certain medicines such as NSAIDs or anticoagulants (warfarin)
  • Are pregnant or breastfeeding — check with your doctor before use


Regular reviews may be recommended if you take it long-term.

FAQ's

Is Nizatidine the same as Famotidine?
Both belong to the H2 blocker family but are different medicines. Your prescriber will recommend the most suitable option.

How quickly does Nizatidine work?
Relief usually begins within an hour, with effects lasting 10–12 hours.

Can I take Nizatidine with PPIs like omeprazole?
Occasionally, yes — but only under medical supervision.

Is Nizatidine still used in the UK?
It is less common than other H2 blockers, but it is still prescribed in certain cases.

Does Nizatidine cure reflux?
It reduces stomach acid and allows healing but is not a permanent cure. Lifestyle changes may also help.

Can I drink alcohol while taking Nizatidine?
Yes, but alcohol may worsen reflux symptoms.