• Reduces stomach acid to treat heartburn and ulcers
  • Provides an effective alternative when PPIs are unsuitable
  • A different mode of action from famotidine-based treatments

How it works?

Online Consultation

We ask you to complete a quick and easy consultation and get you started.

Choose condition

We have a selection of treatments available for various conditions.

Express Delivery

You will have complete visibility and control of your delivery.
Notice!

Before ordering this treatment, you may have to complete an online consultation

Overview

When frequent heartburn and acid reflux keep interfering with daily life, Nizatidine provides reliable relief by tackling stomach acid at its source. As a trusted H2 blocker, Nizatidine helps reduce excess acid, soothe irritation, and prevent painful flare-ups. Taken once or twice daily, it works to protect your oesophagus and restore comfort, so you can enjoy meals and sleep without the constant worry of reflux symptoms.

At SwiftMedi, every request for Nizatidine is carefully reviewed by a UK-registered prescriber through a secure online consultation, with discreet delivery straight to your door.


What is Nizatidine


Nizatidine is part of the group of medicines known as H2 receptor antagonists (H2RAs). It works by blocking the histamine-2 receptors in the stomach lining, which are responsible for triggering acid production. By reducing stomach acid levels, it helps relieve discomfort while allowing the oesophagus and stomach lining to heal.

Nizatidine is prescribed for heartburn and acid reflux, gastro-oesophageal reflux disease (GORD), and for the treatment and prevention of stomach or duodenal ulcers. It is also used in conditions where the stomach produces too much acid, such as Zollinger–Ellison syndrome.

It may be chosen as an alternative to other H2RAs (such as famotidine) or when proton pump inhibitors (PPIs) are not suitable, offering another trusted option for acid control.

Directions

  • Usual adult dose: 150mg twice daily or 300mg once daily, depending on your condition.
  • Can be taken with or without food.
  • Swallow capsules whole with water.
  • Treatment duration varies — typically a few weeks for ulcers or longer for reflux.


Always follow the instructions from your prescriber.

Side Effects

Like all medicines, nizatidine can cause side effects, although not everyone will experience them. Most are mild, short-lived, and improve as your body adjusts to treatment.

Common (may affect up to 1 in 10 people):

  • Headache – usually mild and temporary.
  • Diarrhoea or constipation – digestive changes are generally mild and short-lived.
  • Dizziness – may affect alertness; avoid driving or operating machinery if you feel unwell.


Uncommon (may affect up to 1 in 100 people):

  • Rash or itching – mild skin reactions may occur.
  • Sleep disturbances – difficulty sleeping or vivid dreams have been reported in some cases.
  • Muscle or joint pain – typically mild but should be monitored if persistent.


Rare but serious (seek urgent medical advice):

  • Severe allergic reaction (anaphylaxis) – symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, or a sudden rash.
  • Liver problems – yellowing of the skin or eyes (jaundice), dark urine, or ongoing tiredness may be signs of liver issues.
  • Mood changes or confusion – more likely in older patients; stop treatment and seek medical help if this occurs.


Most people tolerate nizatidine well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Nizatidine may not be suitable if you:

  • Are allergic to Nizatidine or other H2 blockers
  • Have kidney or liver problems — dose adjustments may be needed
  • Are taking certain medicines such as NSAIDs or anticoagulants (warfarin)
  • Are pregnant or breastfeeding — check with your doctor before use


Regular reviews may be recommended if you take it long-term.

Frequently asked questions

  • What is nizatidine and how does it work?

    Nizatidine is an H2 blocker used to treat acid reflux, heartburn and indigestion. It works by reducing the amount of acid the stomach produces, giving relief from burning discomfort and regurgitation. It is often used when a faster-acting option is needed or when PPIs are not suitable.

  • How fast does nizatidine relieve acid reflux or heartburn?

    Many people feel improvement within 30 to 60 minutes, making it one of the quicker non-PPI options for heartburn and acid reflux. Its effect can last up to 12 hours, so some use it as needed for symptom flare-ups. Full benefit is usually seen when taken regularly.

  • How should I take nizatidine for the best effect?

    Take nizatidine with water, usually once or twice daily depending on your plan. Many people take it 30 minutes before meals or at bedtime if symptoms occur at night. Avoid large late meals, caffeine and acidic foods to enhance results. Consistency helps control acid levels.

  • What side effects can nizatidine cause?

    Most people tolerate nizatidine well, but possible side effects include headache, dizziness, stomach discomfort, diarrhoea or constipation. Rare effects may include liver changes or skin rashes. If symptoms worsen or persist, stop taking it and seek advice.

  • Is nizatidine safe for long-term use?

    Nizatidine can be used longer term, but H2 blockers may reduce effectiveness over time, known as tolerance. Periodic reviews help ensure you remain on the right treatment. Long-term users should also address lifestyle triggers to maintain control.

  • Who should not take nizatidine?

    Nizatidine may not be suitable for people with kidney problems, liver issues or a history of stomach bleeding. It should also be avoided if you have unexplained weight loss or swallowing difficulties until assessed. A consultation checks whether it is safe for you.

  • Can nizatidine interact with other medicines?

    Yes. Although interactions are less common than with PPIs, nizatidine may affect the absorption of certain drugs such as antifungals or medicines that require stomach acid for proper uptake. Always mention all tablets you take during your consultation.

  • Is nizatidine weaker or stronger than PPIs like omeprazole?

    Nizatidine works faster, but PPI's usually reduce acid more strongly overall. Many people use nizatidine for short-term flare-ups or when a rapid response is needed, while PPIs are preferred for persistent symptoms. Both can be effective depending on the cause and severity of reflux.

  • Can I take nizatidine at night for night-time reflux?

    Yes. Taking nizatidine at bedtime can help reduce acid production overnight, which is when many people experience their worst symptoms. Elevating the head of the bed and avoiding late meals further improves night-time control.

  • Can nizatidine be combined with antacids or alginates?

    Yes. Antacids and alginates such as Gaviscon can give fast relief while nizatidine works longer term. Leave a one to two hour gap between products to avoid reducing absorption. This combination is helpful during symptom flare-ups.

  • Is nizatidine helpful for indigestion related to alcohol or heavy meals?

    Yes. Many people find nizatidine particularly helpful when reflux or indigestion is triggered by rich foods, large meals or alcohol. It reduces acid spikes that contribute to discomfort. Reducing portion size and avoiding late eating can further improve results.

  • Does nizatidine help prevent reflux caused by exercise or bending?

    It can help reduce the acid levels that contribute to symptoms during physical activity. However, avoiding exercise immediately after meals and choosing upright movements is also important. Clothing that is too tight around the abdomen can worsen symptoms.

  • Can nizatidine be used during pregnancy or breastfeeding?

    Nizatidine is not usually first choice in pregnancy, with antacids or alginates preferred initially. It may be used if benefits outweigh risks. Small amounts may pass into breast milk, so individual advice is recommended.

  • How long should I take nizatidine before stepping down?

    Many people use it for two to six weeks before reviewing symptoms. If things improve, stepping down to occasional use or switching to lifestyle measures may be enough. A clinician can help tailor a plan.

  • What should I do if nizatidine stops working as well as before?

    Some people develop tolerance to H2 blockers, making them less effective over time. If symptoms return, a clinician may suggest switching to a PPI or adjusting your routine. Persistent symptoms should always be assessed.