• Prevents clogged pores by regulating skin cell turnover
  • Reduces redness, swelling, and inflammation linked to acne
  • Gentler than older retinoids, making it suitable for long-term use

How it works?

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Overview

Acne can feel like a constant cycle — new spots appearing just as old ones start to fade. Differin helps break that cycle. Powered by adapalene, a modern retinoid, it works deep within the skin to prevent blocked pores, reduce inflammation, and promote healthy skin renewal.

Used regularly, Differin doesn’t just clear existing breakouts — it helps keep new ones from forming, giving you a clearer, smoother complexion over time. Trusted worldwide by dermatologists, it’s a go-to treatment for those ready to take real control of their acne.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Differin


Differin is a prescription-only topical treatment that contains adapalene, a modern synthetic retinoid. It works by regulating skin cell turnover, helping to prevent clogged pores while also reducing redness and inflammation. This makes it particularly effective for mild to moderate acne, including blackheads, whiteheads, papules, and pustules. Unlike some older retinoids, adapalene is generally gentler on the skin, meaning Differin is often better tolerated for long-term use while still providing powerful results. It is commonly prescribed as a first-line treatment or used alongside other acne medicines, such as benzoyl peroxide or antibiotics, for an even stronger effect.

Directions

  • Apply a thin layer to affected areas once daily in the evening, after cleansing.
  • Use only on the skin — avoid eyes, lips, nostrils, and broken skin.
  • Wash hands after application.
  • Always apply sunscreen during the day, as retinoids increase sensitivity to sunlight.
  • Consistency is key — improvement is usually seen after 6–12 weeks.

Side Effects

Like all medicines, Differin can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people):

  • Dryness or peeling
  • Redness or irritation
  • Mild burning sensation


Less common (may affect up to 1 in 100 people):

  • Skin sensitivity to sunlight
  • Temporary worsening of acne in the first few weeks before it improves


Most people tolerate Differin well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Differin may not be suitable if you:

  • Are pregnant or planning pregnancy (retinoids should not be used)
  • Have very sensitive, eczema-prone skin
  • Are already using other topical retinoids or strong exfoliants


Avoid tanning beds and excessive sun exposure — always wear broad-spectrum SPF.

Frequently asked questions

  • What is Differin Cream and how does it work?

    Differin Cream contains adapalene, a retinoid that helps unclog pores, reduce inflammation and prevent new spots forming. It encourages faster skin turnover, making it particularly effective for blackheads and whiteheads. Many people use Differin when other topical treatments haven’t cleared their acne.

  • How long does Differin Cream take to work?

    Differin Cream usually begins improving acne within four to six weeks, although the full benefit can take up to three months. Some people notice temporary increased breakouts early on as the skin adjusts. Using it consistently gives the best results.

  • How do I apply Differin Cream correctly?

    Apply a thin layer once daily at night to clean, dry skin, avoiding the eyes and mouth. A pea-sized amount is usually enough for the whole face. Using too much can cause irritation but won’t speed up results.

  • What side effects can Differin Cream cause?

    Common side effects include redness, dryness, peeling or mild stinging, especially in the first few weeks. These usually settle as the skin adapts. If the irritation becomes severe, reducing application frequency or adjusting your skincare may help.

  • Who should not use Differin Cream?

    Differin Cream is not recommended if you are pregnant, planning pregnancy or breastfeeding. It may also be unsuitable for people with very sensitive skin or eczema. A clinician can advise on safer alternatives if needed.

  • Can I use Differin Cream with other acne treatments?

    Yes, but combinations must be chosen carefully to avoid irritation. Differin can be paired with benzoyl peroxide or topical antibiotics, but harsh exfoliants or strong acids should be avoided. A clinician can guide the best combination plan.

  • Can I buy Differin Cream online in the UK?

    Yes. Differin Cream is prescription-only and available from regulated UK online pharmacies after a consultation. This ensures it’s safe for your skin type and compatible with any other treatments you use.

  • Is Differin Cream good for blackheads and clogged pores?

    Yes. Differin is particularly effective for blackheads and blocked pores because adapalene helps loosen dead skin cells and prevent new blockages. Many people notice smoother pores and fewer bumps after regular use. It is often chosen when pore congestion is the main issue.

  • Can Differin help hormonal acne?

    Differin can help reduce breakouts linked to hormonal changes by keeping pores clear and calming inflammation. However, deeper cystic outbreaks may need additional treatments such as oral antibiotics or hormonal therapy. A clinician can advise which option suits your pattern of acne.

  • Does Differin Cream help with acne marks or pigmentation?

    Yes. Adapalene can help fade post-acne pigmentation by speeding up skin renewal, although this happens gradually over several weeks to months. It does not treat deeper scarring, which may require other specialist treatments.

  • Should I use Differin Cream in the morning or at night?

    Differin should be applied at night because retinoids can make the skin more sensitive to sunlight. Using it in the evening and applying sunscreen in the daytime helps protect your skin and supports treatment results.

  • Can I wear makeup or skincare products with Differin Cream?

    Yes, but choose gentle, non-comedogenic products and avoid strong acids or scrubs that may increase irritation. Let Differin absorb fully before applying moisturiser or makeup. A simple routine is usually best while your skin adjusts.

  • Why does my acne look worse after starting Differin?

    Some people notice a temporary flare called “retinisation” as pores clear and skin turnover increases. This usually settles within a few weeks. Continuing treatment as advised helps you reach the longer-term benefits.

  • What if Differin Cream isn’t improving my acne?

    If acne hasn’t improved after several weeks, a clinician may suggest combining Differin with benzoyl peroxide, adding an antibiotic gel or considering oral treatments. Different acne types respond to different approaches, so adjusting your plan is often helpful.