• Prevents clogged pores by regulating skin cell turnove
  • Reduces redness, swelling, and inflammation linked to acn
  • Gentler than older retinoids, making it suitable for long-term use

How it works?

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Overview

Acne can feel like a constant cycle — new spots appearing just as old ones start to fade. Differin helps break that cycle. Powered by adapalene, a modern retinoid, it works deep within the skin to prevent blocked pores, reduce inflammation, and promote healthy skin renewal.

Used regularly, Differin doesn’t just clear existing breakouts — it helps keep new ones from forming, giving you a clearer, smoother complexion over time. Trusted worldwide by dermatologists, it’s a go-to treatment for those ready to take real control of their acne.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Differin


Differin is a prescription-only topical treatment that contains adapalene, a modern synthetic retinoid. It works by regulating skin cell turnover, helping to prevent clogged pores while also reducing redness and inflammation. This makes it particularly effective for mild to moderate acne, including blackheads, whiteheads, papules, and pustules. Unlike some older retinoids, adapalene is generally gentler on the skin, meaning Differin is often better tolerated for long-term use while still providing powerful results. It is commonly prescribed as a first-line treatment or used alongside other acne medicines, such as benzoyl peroxide or antibiotics, for an even stronger effect.

Directions

  • Apply a thin layer to affected areas once daily in the evening, after cleansing.
  • Use only on the skin — avoid eyes, lips, nostrils, and broken skin.
  • Wash hands after application.
  • Always apply sunscreen during the day, as retinoids increase sensitivity to sunlight.
  • Consistency is key — improvement is usually seen after 6–12 weeks.

Side Effects

Like all medicines, Differin can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people):

  • Dryness or peeling
  • Redness or irritation
  • Mild burning sensation


Less common (may affect up to 1 in 100 people):

  • Skin sensitivity to sunlight
  • Temporary worsening of acne in the first few weeks before it improves


Most people tolerate Differin well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Differin may not be suitable if you:

  • Are pregnant or planning pregnancy (retinoids should not be used)
  • Have very sensitive, eczema-prone skin
  • Are already using other topical retinoids or strong exfoliants


Avoid tanning beds and excessive sun exposure — always wear broad-spectrum SPF.

FAQ's

How does Differin work?
Differin speeds up skin cell turnover, helping unclog pores and reduce inflammation, while preventing new spots from forming.

How long does Differin take to work?
Most people see noticeable improvement within 8–12 weeks of consistent use.

Will my acne get worse before it gets better?
Yes, some people notice an initial flare-up in the first few weeks — this is normal and temporary.

Can Differin be used with moisturisers?
Yes — in fact, pairing Differin with a gentle, non-comedogenic moisturiser helps reduce dryness.

Is Differin suitable for teenagers?
Yes — it is commonly prescribed for teenagers with persistent acne.

Can Differin be used on body acne?
Yes, it can also be applied to areas like the chest or back, if advised by your prescriber.