• Combines a retinoid and antibacterial treatment in one powerful formula
  • Targets clogged pores, excess oil, and acne-causing bacteria simultaneously
  • Proven effective where single treatments alone have not worked

How it works?

Online Consultation

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We have a selection of treatments available for various conditions.

Express Delivery

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Before ordering this treatment, you may have to complete an online consultation

Overview

When acne keeps coming back, Epiduo offers a powerful two-in-one solution. By combining adapalene (a retinoid) with benzoyl peroxide, it works on the surface and deep within the skin to clear existing spots, unclog pores, reduce inflammation, and prevent new breakouts.

Epiduo is trusted worldwide as a first-line treatment for mild to moderate acne. Used daily, it not only helps clear current flare-ups but also breaks the cycle of recurring spots, giving you the chance to regain control of your skin — and your confidence.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Epiduo


Epiduo is a prescription topical gel and one of the most commonly prescribed treatments for acne. It combines two active ingredients that work in complementary ways. Adapalene (0.1%), a modern retinoid, helps regulate skin cell turnover to keep pores clear while reducing inflammation. Benzoyl peroxide (2.5%) targets the bacteria that causes acne and helps reduce excess oil. By addressing multiple causes of acne at the same time, Epiduo provides a dual-action approach that is particularly effective for people who have not achieved results with single treatments alone.

Directions

  • Apply a thin layer once daily in the evening to clean, dry skin.
  • Use only on affected areas — avoid the eyes, lips, nostrils, and broken skin.
  • Always wash hands after applying.
  • Use a gentle cleanser and moisturiser to reduce dryness.
  • Apply sunscreen during the day, as Epiduo can make your skin more sensitive to sunlight.


Results are usually noticeable after 4–8 weeks of consistent use, with further improvements over several months.

Side Effects

Like all medicines, Epiduo can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people):

  • Dryness, peeling, or flaking
  • Redness
  • Mild burning or stinging


Less common (may affect up to 1 in 100 people):

  • Skin irritation that does not settle after a few weeks
  • Increased sensitivity to sunlight


Most people tolerate Epiduo well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Epiduo may not be suitable if you:

  • Are pregnant or planning pregnancy (retinoids should not be used)
  • Have very sensitive or eczema-prone skin
  • Are using other retinoid creams or strong acne treatments


Avoid excessive sun exposure and tanning beds — always wear broad-spectrum SPF while on treatment.

Frequently asked questions

  • What is Epiduo Gel and how does it work?

    Epiduo Gel combines adapalene, a retinoid that unclogs pores, with benzoyl peroxide, which kills acne-causing bacteria. The two ingredients work together to reduce inflammation, prevent blocked pores and limit new breakouts. It’s often used for acne that hasn’t improved with single treatments.

  • How long does Epiduo Gel take to work?

    Epiduo Gel usually starts working within a few weeks, although the full benefit can take eight to twelve weeks. Some people notice early redness or a brief flare as the skin adjusts. Using it consistently gives the strongest long-term improvement.

  • How do I apply Epiduo Gel correctly?

    Apply a thin layer once daily at night to clean, dry skin, avoiding the eyes and mouth. A pea-sized amount is usually enough for the whole face. Using more than advised increases irritation but doesn’t speed up results.

  • What side effects can Epiduo Gel cause?

    The most common effects are dryness, redness, peeling and mild stinging, especially in the first weeks. These usually settle as your skin adapts. If irritation is severe, a clinician may recommend adjusting how often you apply it.

  • Who should not use Epiduo Gel?

    Epiduo Gel is not suitable during pregnancy or while planning pregnancy. It may also be unsuitable for people with very sensitive skin, eczema or rosacea. Your clinician can assess whether it’s the right option for your acne type.

  • Is Epiduo Gel stronger than Differin or benzoyl peroxide alone?

    Yes. Epiduo combines two proven acne treatments, making it more effective for many people with mixed or inflamed acne. The dual action targets clogged pores and bacteria at the same time, though it may cause more dryness than single-ingredient gels.

  • Can I buy Epiduo Gel online in the UK?

    Yes. Epiduo Gel is prescription-only and available from regulated UK online pharmacies after a consultation. This ensures it’s suitable for your skin and safe alongside any other treatments you use.

  • Is Epiduo Gel suitable for inflamed or cystic acne?

    Epiduo Gel is effective for mild to moderate inflammatory acne because it reduces bacteria and unclogs pores. For deeper cystic acne, additional treatments such as oral antibiotics or stronger retinoids may be needed. Your clinician can tailor a plan based on your acne severity.

  • Can Epiduo help with blackheads and whiteheads?

    Yes. The adapalene component helps prevent pore blockages, while benzoyl peroxide reduces the inflammation that can form around clogged pores. Many people see clearer texture and fewer bumps after several weeks of consistent use.

  • Why does Epiduo Gel cause dryness or peeling?

    Dryness is common because adapalene increases skin turnover and benzoyl peroxide can be drying on its own. These effects usually improve once your skin adapts. Using a gentle, non-comedogenic moisturiser can help maintain comfort during treatment.

  • Can I use moisturiser, makeup or other skincare with Epiduo?

    Yes. Apply moisturiser after Epiduo has absorbed, or before as a buffer if your skin is sensitive. Choose non-comedogenic products and avoid harsh scrubs or strong acids. Light makeup is fine once your skin is comfortable.

  • Will Epiduo bleach fabrics or clothing?

    Yes, the benzoyl peroxide in Epiduo can bleach towels, bedding and clothing. Let the gel dry completely before dressing and wash your hands after applying it. Taking care helps avoid accidental bleaching.

  • Should I avoid sunlight while using Epiduo Gel?

    Yes. Epiduo makes your skin more sensitive to sunlight, increasing the risk of redness or irritation. Daily sunscreen and avoiding strong sun exposure help protect your skin during treatment.

  • What if Epiduo Gel doesn’t improve my acne?

    If your acne hasn’t improved after several weeks, your clinician may recommend adjusting how you use Epiduo, adding another topical agent or considering oral treatments. Treatment plans often need small changes before you find the right combination.