• Combines a retinoid and antibacterial treatment in one powerful formula
  • Targets clogged pores, excess oil, and acne-causing bacteria simultaneously
  • Proven effective where single treatments alone have not worked

How it works?

Online Consultation

We ask you to complete a quick and easy consultation and get you started.

Choose condition

We have a selection of treatments available for various conditions.

Express Delivery

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Notice!

Before ordering this treatment, you may have to complete an online consultation

Overview

When acne keeps coming back, Epiduo offers a powerful two-in-one solution. By combining adapalene (a retinoid) with benzoyl peroxide, it works on the surface and deep within the skin to clear existing spots, unclog pores, reduce inflammation, and prevent new breakouts.

Epiduo is trusted worldwide as a first-line treatment for mild to moderate acne. Used daily, it not only helps clear current flare-ups but also breaks the cycle of recurring spots, giving you the chance to regain control of your skin — and your confidence.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Epiduo


Epiduo is a prescription topical gel and one of the most commonly prescribed treatments for acne. It combines two active ingredients that work in complementary ways. Adapalene (0.1%), a modern retinoid, helps regulate skin cell turnover to keep pores clear while reducing inflammation. Benzoyl peroxide (2.5%) targets the bacteria that causes acne and helps reduce excess oil. By addressing multiple causes of acne at the same time, Epiduo provides a dual-action approach that is particularly effective for people who have not achieved results with single treatments alone.

Directions

  • Apply a thin layer once daily in the evening to clean, dry skin.
  • Use only on affected areas — avoid the eyes, lips, nostrils, and broken skin.
  • Always wash hands after applying.
  • Use a gentle cleanser and moisturiser to reduce dryness.
  • Apply sunscreen during the day, as Epiduo can make your skin more sensitive to sunlight.


Results are usually noticeable after 4–8 weeks of consistent use, with further improvements over several months.

Side Effects

Like all medicines, Epiduo can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people):

  • Dryness, peeling, or flaking
  • Redness
  • Mild burning or stinging


Less common (may affect up to 1 in 100 people):

  • Skin irritation that does not settle after a few weeks
  • Increased sensitivity to sunlight


Most people tolerate Epiduo well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Epiduo may not be suitable if you:

  • Are pregnant or planning pregnancy (retinoids should not be used)
  • Have very sensitive or eczema-prone skin
  • Are using other retinoid creams or strong acne treatments


Avoid excessive sun exposure and tanning beds — always wear broad-spectrum SPF while on treatment.

FAQ's

How does Epiduo work?
It combines adapalene (to unclog pores and reduce inflammation) with benzoyl peroxide (to kill acne bacteria and dry excess oil).

How long does Epiduo take to work?
Most people see improvements within 4–8 weeks, but full results may take several months.

Will my acne get worse before it gets better?
Yes, some people notice an initial flare-up in the first 2–4 weeks — this is normal and usually temporary.

Can I use Epiduo with moisturisers?
Yes — a non-comedogenic moisturiser can help reduce dryness and irritation.

Is Epiduo stronger than Differin?
Epiduo is often more effective because it combines adapalene with benzoyl peroxide, tackling acne from multiple angles.

Can teenagers use Epiduo?
Yes — it is commonly prescribed for teenagers with moderate acne.