• Targets acne-causing bacteria to reduce infection and inflammation
  • Unclogs pores and prevents new spots from forming
  • Effective for both inflammatory and comedonal acne 

How it works?

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Before ordering this treatment, you may have to complete an online consultation

Overview

Treclin Gel brings together two proven acne-fighting ingredients in one treatment — clindamycin to kill bacteria and reduce inflammation, and tretinoin to keep pores clear and prevent new spots forming.

This combination not only works on active breakouts but also helps reduce blackheads and whiteheads, giving your skin the chance to heal and stay clearer over time. It’s often prescribed when single treatments haven’t been enough, making it a trusted next step for many acne sufferers.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Treclin Gel


Treclin Gel is a prescription topical treatment that combines two active ingredients for a comprehensive approach to acne. Clindamycin (1%), an antibiotic, works to reduce acne-causing bacteria and calm inflammation, while tretinoin (0.025%), a retinoid, helps to increase skin cell turnover, unclog pores, and prevent new breakouts from forming. This dual-action formula makes Treclin effective for both inflammatory acne (red, sore spots) and comedonal acne (blackheads and whiteheads), helping to address multiple causes of acne and break the cycle of recurring flare-ups.

Directions

  • Apply a thin layer once daily in the evening to clean, dry skin.
  • Use only on affected areas — avoid the eyes, lips, nostrils, and broken skin.
  • Wash hands after applying.
  • Expect some initial irritation — redness, dryness, or peeling are common at first and usually improve over time.
  • Always wear sunscreen during the day, as tretinoin increases sun sensitivity.


Visible improvement usually occurs within 6–8 weeks, with clearer skin continuing over several months.

Side Effects

Like all medicines, Treclin Gel can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people, especially in the first few weeks):

  • Redness
  • Dryness or peeling
  • Mild burning or stinging


Less common (may affect up to 1 in 100 people):

  • Persistent irritation that does not settle
  • Increased sensitivity to sunlight


Rare (may affect up to 1 in 1,000 people):

  • Allergic reaction (stop treatment and seek medical advice if severe)


Most people tolerate Treclin Gel well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Treclin may not be suitable if you:

  • Are pregnant or planning pregnancy (tretinoin must not be used)
  • Are breastfeeding (should be avoided unless specifically advised)
  • Have very sensitive or eczema-prone skin
  • Are using other strong acne treatments (such as oral retinoids)


Always avoid tanning beds and protect your skin with a broad-spectrum SPF daily.

Frequently asked questions

  • What is Treclin Gel and how does it work?

    Treclin Gel contains clindamycin, an antibiotic that reduces bacteria, and tretinoin, a retinoid that unblocks pores and reduces inflammation. This combination makes it effective for red, inflamed and clogged acne that hasn’t responded to milder treatments.

  • How long does Treclin Gel take to work?

    Treclin often begins improving acne within two to four weeks, with clearer results taking eight to twelve weeks. Some people experience early irritation or a flare as pores start to clear. Consistent, daily use helps achieve full benefit.

  • How do I apply Treclin Gel correctly?

    Apply a thin layer once daily in the evening to clean, dry skin, avoiding the eyes and mouth. A pea-sized amount is usually enough for the whole face. Using more than advised increases irritation without improving results.

  • What side effects can Treclin Gel cause?

    Common side effects include redness, peeling, dryness, burning or mild stinging, especially during the first few weeks. These usually settle as your skin adjusts. If irritation becomes severe, reducing application frequency may help.

  • Who should not use Treclin Gel?

    Treclin is not suitable during pregnancy or when planning pregnancy. It may also be unsuitable if you have very sensitive skin, eczema, or a history of bowel conditions linked to antibiotic use. A clinician will check it’s appropriate.

  • Is Treclin stronger than Duac or Epiduo?

    Treclin may be stronger for clogged pores and inflamed bumps because tretinoin helps prevent deep blockages while clindamycin reduces bacteria. It can be more irritating than Duac and works differently to Epiduo, so choice depends on your acne type and skin sensitivity.

  • Can I buy Treclin Gel online in the UK?

    Yes. Treclin is prescription-only and available from regulated UK online pharmacies after completing a consultation. This ensures it’s safe, used for the right duration and appropriate for your acne.

  • Is Treclin Gel good for inflamed or cystic acne?

    Treclin works well for mild to moderate inflammatory acne because it targets both bacteria and blocked pores. For deeper cystic acne, additional treatments such as oral antibiotics or stronger retinoids may be recommended. Your clinician can guide the best approach for your skin.

  • Can Treclin help with blackheads and whiteheads?

    Yes. The tretinoin in Treclin helps clear blocked pores and prevent new blackheads or whiteheads from forming. Many people see smoother texture and fewer bumps after several weeks of consistent use.

  • Why is Treclin only used for limited treatment courses?

    Treclin contains an antibiotic, so it’s prescribed for time-limited courses to prevent antibiotic resistance. Once inflammation improves, clinicians often switch to a non-antibiotic retinoid for maintenance.

  • Can I use moisturiser, makeup or skincare with Treclin?

    Yes. Gentle, non-comedogenic products are usually fine. Apply moisturiser after Treclin has absorbed, or apply it beforehand if your skin needs buffering. Avoid harsh scrubs or strong acids, as these can increase irritation.

  • Should I avoid the sun while using Treclin Gel?

    Yes. Tretinoin increases sun sensitivity, making redness or irritation more likely. Use sunscreen daily and avoid strong sun exposure to keep your skin comfortable during treatment.

  • Can Treclin help with acne marks or texture?

    Treclin can help fade dark marks and improve uneven texture because tretinoin increases skin turnover. Improvements appear slowly over several weeks. It does not treat deep scars, which may require specialist procedures.

  • What if Treclin Gel doesn’t improve my acne?

    If Treclin hasn’t helped after several weeks, a clinician may change your routine, combine it with additional treatments or consider oral medicines. Acne often responds best to a personalised plan tailored to your skin.