• Shortens outbreaks when taken at the first sign of symptoms
  • Eases pain, itching, and blisters during flare-ups
  • Can be taken long-term to help prevent frequent or severe recurrences

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Overview

Struggling with the pain and discomfort of a genital herpes outbreak? Aciclovir Tablets are a trusted first-line antiviral treatment that help to ease symptoms, speed up healing, and reduce the severity of future flare-ups.

By stopping the herpes simplex virus (HSV) from multiplying, Aciclovir helps blisters heal faster and prevents the outbreak from spreading. Many patients find that starting treatment at the first signs of tingling or discomfort makes outbreaks shorter and more manageable.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Aciclovir 


Aciclovir Tablets are a reliable and widely prescribed treatment for genital herpes.
They work by stopping the herpes simplex virus (HSV) from multiplying, which helps your immune system take control of the outbreak and speeds up recovery.

Taken at the first signs of symptoms, Aciclovir can:

  • Shorten the duration of an active outbreak
  • Reduce pain, burning, and discomfort
  • Help blisters heal faster and minimise inflammation
  • Lower the risk of future flare-ups when used long-term as suppressive treatment


Aciclovir is a trusted option for both first-time and recurring outbreaks — offering relief, control, and peace of mind.

Directions

  • Always take as prescribed by your clinician.
  • For an outbreak, the usual dose is 400mg three times daily for 5 days.
  • For suppressive therapy (frequent outbreaks), lower daily doses may be prescribed.
  • Swallow the tablets whole with water, with or without food.
  • Begin treatment as soon as the first symptoms appear for the best results.

Side Effects

Most people tolerate Aciclovir well, and side effects are usually mild and short-lived. However, like all medicines, it can occasionally cause unwanted effects.

Common (may affect up to 1 in 10 people):

  • Nausea or stomach upset – taking Aciclovir with food may help reduce this.
  • Headache – usually mild and temporary.
  • Diarrhoea – stay hydrated and speak to your doctor if persistent.
  • Tiredness – some people feel more fatigued during treatment.


Less common but serious (seek medical advice):

  • Allergic reaction – symptoms include rash, itching, swelling, or difficulty breathing.
  • Kidney problems – more likely if dehydrated or taking other medications that affect the kidneys.
  • Confusion or dizziness – rare, but more likely in older adults or people with kidney issues.


Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet that comes with your medicine for full details. If you notice anything unusual or concerning, stop taking the medicine and seek medical advice promptly. In an emergency, call 999 or go to A&E.

Warnings

Do not take Aciclovir if you:

  • Are allergic to aciclovir, valaciclovir, or any ingredients in the tablets


Other cautions:

  • Drink plenty of fluids while taking this medicine
  • Tell your prescriber about other medicines you’re using
  • Pregnant or breastfeeding? Use only under medical supervision
  • People with kidney problems may need dose adjustments
Frequently asked questions
  • What are aciclovir tablets and how do they treat genital herpes?

    Aciclovir tablets are antiviral medicine that reduce the severity and length of genital herpes outbreaks. They work by slowing viral replication so symptoms improve sooner. Early treatment helps with pain and speeds healing during both first and recurrent episodes.

  • How quickly do aciclovir tablets work during an outbreak?

    Aciclovir often starts easing symptoms within a couple of days, although healing takes longer. Starting treatment at the first sign of tingling or soreness usually produces the best results. Pain and blistering tend to improve sooner when treatment begins early.

  • What dose of aciclovir is used for genital herpes?

    A typical outbreak dose is 400mg three times daily for five days, although prescribers may adjust this for first episodes or severe symptoms. Following the full course helps recovery and reduces viral shedding. Tablets should be taken with water and spaced evenly through the day.

  • Can aciclovir prevent future outbreaks?

    Yes. Aciclovir can be taken daily as suppressive therapy if you experience frequent or distressing outbreaks. This approach reduces how often symptoms occur and lowers the risk of passing herpes to a partner. Your clinician will advise the right dose for long-term use.

  • Is aciclovir safe, and what side effects should I expect?

    Most people tolerate aciclovir well. Mild side effects like nausea, headache, diarrhoea or tiredness can occur but usually settle quickly. Serious effects are rare. Drinking plenty of water helps your kidneys process the medicine safely. Speak to a clinician if symptoms persist.

  • What should I do if I miss a dose of aciclovir?

    If you miss a dose, take it as soon as you remember unless it is nearly time for the next one. Do not double up. Keeping doses evenly spaced helps maintain antiviral levels and supports quicker healing during an outbreak.

  • Is aciclovir suitable for everyone with genital herpes?

    Aciclovir suits most adults, but your prescriber will check kidney health, other medicines and whether you are pregnant or breastfeeding. Some people may benefit more from valaciclovir due to simpler dosing or frequent outbreaks. A clinician will help choose the best option.

  • When should I start aciclovir for the best results?

    The earlier you start aciclovir, the better it works. Beginning treatment at the first signs of tingling, soreness or redness can prevent a full outbreak and shorten recovery time. If symptoms already blistered, it can still help, but results may be slower.

  • Can I take aciclovir long term for suppression?

    Yes. Many people use aciclovir daily for suppression when outbreaks are frequent or emotionally distressing. Long-term use is generally safe when monitored. It can reduce outbreaks significantly and help people feel more in control of symptoms.

  • Does aciclovir reduce the risk of passing herpes to a partner?

    Yes. Aciclovir reduces viral shedding, especially when taken daily, which lowers the risk of transmission. Condoms further reduce risk, and avoiding sex during symptoms remains important. Suppression therapy can be useful in new relationships or when a partner is uninfected.

  • Can I drink alcohol while taking aciclovir?

    Moderate alcohol is generally safe with aciclovir, but drinking heavily may worsen tiredness or dehydration, slowing recovery from an outbreak. Staying well hydrated helps aciclovir work effectively. If alcohol makes you feel unwell while taking it, limit consumption.

  • Can aciclovir be used during pregnancy?

    Aciclovir is often considered safe in pregnancy when needed, especially during a first outbreak or close to delivery. Your doctor or midwife will advise whether treatment is appropriate and may recommend suppression late in pregnancy to reduce risks.

  • What is the difference between aciclovir and valaciclovir?

    Both treat genital herpes, but valaciclovir is absorbed more effectively, allowing less frequent dosing. Some people prefer valaciclovir for convenience, while others stay with aciclovir because it works well and is widely used. Your prescriber can help choose between them.

  • Why might aciclovir not work as well during a severe first outbreak?

    First outbreaks can be more intense because your immune system has not encountered the virus before. Aciclovir still helps but may take longer to relieve symptoms. Pain relief, salt baths and hydration can support recovery alongside antivirals.

  • Should I use topical aciclovir cream as well as tablets?

    Tablets are the main treatment for genital herpes. Topical aciclovir cream is designed for cold sores and offers little benefit for genital outbreaks. Tablets reach the affected nerves more effectively and are preferred for both first and recurrent episodes.

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