Colofac 200mg MR is a modified-release form of mebeverine designed to relax bowel muscles gradually throughout the day. It helps reduce gripping pain, cramping and digestive discomfort linked to IBS by calming spasms in the gut. The slow-release action makes it especially useful for people who want more consistent symptom control rather than short bursts of relief.

Colofac 200mg MR releases mebeverine slowly, providing longer-lasting relief from cramping and spasms. The 135mg version releases the medicine immediately and is usually taken more often. People with all-day symptoms often prefer the MR capsules for convenience and smoother symptom control across the day.

Yes. The modified-release formulation maintains steadier levels of mebeverine, making it helpful for ongoing discomfort rather than short episodes. It works gradually to reduce spasms throughout the day, which can make flare ups less frequent and less intense. People with unpredictable or chronic IBS often find it provides smoother coverage.

The usual adult dose is one capsule twice daily, swallowed whole with water. Do not crush or chew the capsule, as this disrupts the modified-release mechanism. Take doses at the same times each day for consistent relief. If symptoms remain or worsen, seek a review to adjust treatment.

Colofac 200mg MR is usually well tolerated. Possible side effects include mild nausea, headache, indigestion or skin irritation. These are typically short-lived. Serious reactions such as swelling, rash or breathing difficulties are rare but require urgent medical help. If symptoms persist, a clinician may recommend adjusting the dose or switching treatments.

You should avoid Colofac 200mg MR if you have paralytic ileus, severe bowel disease, or an allergy to mebeverine. Caution is recommended for pregnant or breastfeeding individuals, and those taking other gut-acting medicines. Always seek advice if your symptoms include red flags like weight loss, bleeding or persistent changes.

Yes. Many people switch to the 200mg MR capsules if they need longer coverage or prefer fewer daily doses. A clinician may suggest the modified-release version if your symptoms occur throughout the day or if you struggle with meal-timed dosing. Always follow medical advice when changing formulations.

Yes. The modified-release design provides a gradual effect that suits people living with persistent daily discomfort. By keeping the bowel muscles relaxed for longer periods, it can reduce the intensity and frequency of chronic spasms. It is often used alongside diet changes or stress-reduction strategies for broader symptom control.

Colofac 200mg MR can be taken with or without food, but taking it at consistent times helps maintain symptom control. Some people prefer taking it before meals if eating tends to trigger their IBS flare ups. Avoid crushing the capsule, as this prevents proper release of the medicine.

Many people find the MR capsules reduce flare ups because the medication stays active for longer. This can help stabilise symptoms across the day rather than just after meals. It may be especially helpful if you have unpredictable or frequent cramping..

Yes. Taking a capsule in the morning can provide coverage during the early hours when many people experience heightened sensitivity. Because the medicine releases slowly, it helps reduce spasms as your digestive system becomes more active. Adjusting dose timing may optimise relief. 

Yes. Colofac reduces background spasms, while Buscopan can help with sudden sharp episodes. Peppermint oil can also reduce bloating or pressure. This layered approach often supports broader control,  but check with a clinician if taking multiple gut-acting medicines routinely.

Colofac 200mg MR can help reduce spasms caused by stress-related gut sensitivity. Because it works gradually, it may soften the overall intensity of flare ups. Combining the capsules with stress-management techniques often leads to better long-term results.

If symptoms remain despite consistent use, review your diet, stress triggers and dosing schedule. A clinician may suggest adding another antispasmodic, switching to a different formulation or exploring dietary approaches such as low-FODMAP guidance.

Most people see some improvement within a few days, but a full assessment usually takes one to two weeks. If symptoms significantly improve, continuing the treatment may help maintain control. If little changes, review your plan with a clinician.