• Specifically effective for period pain relief
  • Blocks pain and inflammation at the source
  • Also treats muscle, back and dental pain

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Overview

Mefenamic acid is a proven prescription painkiller that’s often used for period cramps, easing the abdominal and back pain that so often disrupt your day. By targeting the cause of pain and inflammation, it provides fast, reliable relief - not just for menstrual pain, but also for muscle aches, back pain, and dental pain.

 

What is Mefenamic acid

Mefenamic acid is a prescription-only non-steroidal anti-inflammatory drug (NSAID) that works by blocking the body’s production of prostaglandins - natural chemicals that trigger pain, inflammation, and muscle contractions. By reducing these chemicals, mefenamic acid provides effective relief from moderate pain and discomfort.

It is especially effective for period pain (dysmenorrhoea), where it helps ease abdominal cramps, back pain, and pelvic discomfort caused by uterine contractions. Unlike standard painkillers, mefenamic acid doesn’t just dull the pain - it actively reduces the inflammation that causes it, helping you feel more comfortable and in control throughout your cycle.

In addition to menstrual pain, mefenamic acid can also be prescribed for muscle aches, back pain, dental pain, and mild arthritis-related discomfort, offering flexible, targeted relief when ordinary painkillers aren’t enough.

Because it tackles both pain and inflammation, many people find it not only relieves discomfort but also helps restore energy and movement - allowing them to get back to their day with minimal disruption.

Directions

  • Usual adult dose: 500mg initially, followed by 250mg every 6 hours as required.
  • Take with food or milk to reduce stomach irritation.
  • Do not exceed the maximum daily dose recommended by your prescriber.
  • Use the lowest effective dose for the shortest possible time.

Side Effects

Mefenamic acid is generally well tolerated, but side effects may occur.

Common (may affect up to 1 in 10 people):

  • Indigestion or stomach pain
  • Nausea or diarrhoea
  • Heartburn


Uncommon (may affect up to 1 in 100 people):

  • Headache or dizziness
  • Constipation or bloating
  • Rash or itching


Rare but serious (seek urgent help):

  • Severe stomach pain, vomiting blood, or black stools (signs of bleeding)
  • Chest pain or shortness of breath (possible heart-related side effects)
  • Severe allergic reaction (swelling, rash, difficulty breathing)


Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet that comes with your medicine for full details. If you notice anything unusual or concerning, stop taking mefenamic acid and seek medical advice promptly. In an emergency, call 999 or go to A&E.

Warnings

  • Not suitable if you have a history of stomach ulcers, bleeding disorders, severe kidney or liver problems, or certain heart conditions.
  • Avoid if allergic to mefenamic acid, aspirin, or other NSAIDs.
  • Not recommended in late pregnancy.
  • Use with caution if taking blood thinners, corticosteroids, SSRIs, or other NSAIDs.
  • Limit alcohol while taking to reduce risk of stomach irritation.
Frequently asked questions
  • What is mefenamic acid 250 mg and how does it work?

    Mefenamic acid is an anti-inflammatory medicine used for short-term pain relief. It works by reducing prostaglandins, chemicals that cause inflammation and cramping. This helps ease period pain, muscle aches and mild injury-related discomfort.

  • What is mefenamic acid used for?

    Mefenamic acid is commonly prescribed for period pain, pelvic cramping, muscle pain, toothache and pain related to minor injuries. Because it reduces both inflammation and spasm-type discomfort, many people find it particularly effective for menstrual symptoms.

  • How should I take mefenamic acid 250 mg capsules?

    Take one capsule up to three times daily with food, usually for the shortest time needed. Swallow it with water and avoid taking more than the prescribed dose. Do not combine it with other anti-inflammatories unless a clinician advises otherwise.

  • How long does mefenamic acid take to work?

    Relief often begins within one hour, with the full effect developing as inflammation reduces. Taking the capsule regularly during the first day of symptoms usually provides better control, especially for period pain.

  • What are the common side effects?

    Side effects may include stomach discomfort, nausea, indigestion, diarrhoea or headache. Taking the capsule with food reduces irritation. Seek urgent help if you notice black stools, vomiting blood or severe abdominal pain.

  • Who should not take mefenamic acid?

    Avoid it if you have stomach ulcers, severe heart, kidney or liver disease, or if you are in late pregnancy. People taking blood thinners, lithium or other anti-inflammatories should check with a clinician first.

  • Can I take mefenamic acid with other painkillers?

    Yes. It can be used with paracetamol, which works differently. Avoid taking it with ibuprofen, naproxen or aspirin unless specifically advised, as this increases the chance of stomach irritation.

  • Is mefenamic acid good for heavy or painful periods?

    Yes. Mefenamic acid is one of the most effective treatments for painful periods and can also reduce heavy bleeding in some people. It works best when started at the first sign of cramps and continued for a few days.

  • Can mefenamic acid help with pain linked to IUD use?

    Mefenamic acid can help reduce cramping associated with copper IUDs, especially during the first few months after insertion. If pain remains severe or long-lasting, it is important to seek further clinical advice.

  • Should I take mefenamic acid with food?

    Yes. Always take mefenamic acid with meals or a snack, as this significantly reduces stomach irritation. Even people with strong digestion can develop discomfort if they use it on an empty stomach.

  • Can I drink alcohol while taking mefenamic acid?

    Light drinking is generally safe, but alcohol increases the risk of stomach irritation and indigestion. People with reflux, ulcers or sensitive digestion should avoid alcohol while taking anti-inflammatories.

  • Is mefenamic acid safe for regular monthly use?

    Many people use it safely for several days each month. However, those with stomach issues, long-term health conditions or frequent heavy bleeding should have regular reviews to ensure continued safety.

  • Can mefenamic acid cause stomach problems even if taken correctly?

    Yes. While food reduces irritation, anti-inflammatories can still cause indigestion or, rarely, ulcers. People with a history of stomach issues may need an alternative or a protective medicine. Monitor for persistent discomfort.

  • What should I do if mefenamic acid does not relieve my pain?

    If symptoms persist despite correct dosing, you may benefit from switching to a different anti-inflammatory or combining treatment with paracetamol. Ongoing severe pain may require assessment for other causes.

  • Can I buy mefenamic acid online in the UK?

    Yes. It can be supplied from a registered UK pharmacy after a brief consultation to check it is safe for you. You may be asked about stomach problems, pregnancy, other medicines and any health conditions before approval.