• A powerful NSAID for quick and effective pain relief
  • Relieves muscle, back, dental, and period pain 
  • Flexible formulations to suit short-term use or ongoing treatment

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Overview

Naproxen is a powerful anti-inflammatory painkiller trusted by millions worldwide. Whether it’s back pain that keeps you stiff, muscle aches after injury, a throbbing toothache, or painful period cramps, Naproxen provides fast, reliable relief so you can get back to living your life.
Available in immediate-release for quick relief and gastro-resistant tablets for longer-term comfort.


Living with such pain can drain your energy, interrupt your sleep, and make even simple daily tasks feel overwhelming. Naproxen offers dependable relief from a wide range of painful conditions — including muscle pain, back pain, dental pain, and period cramps.

As part of the NSAID (non-steroidal anti-inflammatory drug) family, Naproxen works by targeting the source of pain and inflammation, not just masking the symptoms. That means less stiffness, reduced swelling, and lasting comfort.

  • Immediate-release tablets act fast, making them ideal for flare-ups.
  • Gastro-resistant tablets are specially designed to protect the stomach, making them suitable for people who need treatment over a longer period.


Trusted, versatile, and effective - Naproxen is one of the go-to prescription painkillers for both short-term and ongoing relief.

Directions

  • Typical dose: 250mg–500mg, taken 2–3 times daily with food (dose depends on the condition being treated).
  • Always take with a meal or snack to reduce stomach irritation.
  • Do not exceed the maximum prescribed daily dose.
  • Use the lowest effective dose for the shortest possible time.
  • Gastro-resistant tablets should be swallowed whole — do not crush or chew.

Side Effects

Like all NSAIDs, Naproxen may cause side effects, though many people tolerate it well.

Common (may affect up to 1 in 10 people):

  • Indigestion or stomach pain
  • Heartburn
  • Nausea


Less common (may affect up to 1 in 100 people):

  • Headache or dizziness
  • Diarrhoea or constipation
  • Skin rash or itching


Rare but serious (seek urgent medical help):

  • Severe stomach pain, vomiting blood, or black stools (signs of stomach bleeding)
  • Chest pain or shortness of breath (possible heart-related side effects)
  • Severe allergic reaction (swelling, rash, difficulty breathing)


Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet that comes with your medicine for full details. If you notice anything unusual or concerning, stop taking Naproxen and seek medical advice promptly. In an emergency, call 999 or go to A&E.

Warnings

  • Not suitable if you have a history of stomach ulcers, bleeding disorders, severe kidney or liver problems, or certain heart conditions.
  • Avoid if allergic to naproxen, aspirin, or other NSAIDs.
  • Not recommended in pregnancy (especially in the last trimester).
  • Limit alcohol while taking naproxen, as it increases stomach irritation.
  • Tell your prescriber if you take blood thinners, corticosteroids, SSRIs, or other NSAIDs.
Frequently asked questions
  • What are naproxen gastro-resistant tablets and how do they work?

    Naproxen gastro-resistant tablets contain the same active ingredient as standard naproxen but are coated so they dissolve lower in the gut. This helps reduce stomach irritation while still providing anti-inflammatory and pain-relieving effects. They are useful when inflammation needs steady control through the day.

  • Why are naproxen gastro-resistant tablets different from standard naproxen?

    Gastro-resistant tablets are designed to protect the stomach by delaying release until the medicine passes through the upper digestive system. This makes them more suitable for people who experience indigestion with ordinary naproxen or need longer courses for inflammatory conditions. They work in the same way but are gentler on the stomach.

  • How long do gastro-resistant tablets take to start working?

    Because the tablets are designed to dissolve further down the gut, they may take slightly longer to start working compared with standard naproxen. Most people feel relief within one to two hours. The anti-inflammatory effects build gradually with regular dosing.

  • What conditions are naproxen gastro-resistant tablets used for?

    They are used for musculoskeletal pain, arthritis, tendon inflammation, period pain and conditions where long-lasting anti-inflammatory support is needed. The gastro-resistant coating makes them a better option for people who cannot tolerate ordinary naproxen.

  • How do I take naproxen gastro-resistant tablets safely?

    Swallow the tablets up to twice a day with water and avoid crushing or chewing them, as this damages the protective coating. Take the lowest dose needed for the shortest duration. Avoid combining them with other anti-inflammatory medicines unless discussed with a clinician.

  • What are the common side effects of gastro-resistant naproxen?

    Common side effects include indigestion, nausea, stomach discomfort, headache and dizziness. While the coating provides some stomach protection, irritation can still occur. Seek urgent help if you notice black stools, vomiting blood or severe abdominal pain.

  • Who should not take naproxen gastro-resistant tablets?

    They are unsuitable for people with stomach ulcers, bleeding disorders, severe heart or kidney disease, or those in late pregnancy. People taking blood thinners or certain blood pressure medicines may also need caution. Always check with a clinician before starting treatment.

  • Can I take gastro-resistant naproxen if I have a sensitive stomach?

    Many people with mild stomach sensitivity tolerate the gastro-resistant version better because the coating reduces exposure to the stomach lining. However, it does not remove all risk. Anyone with a history of ulcers or severe reflux should discuss suitability with a clinician before using it.

  • Can I combine gastro-resistant naproxen with paracetamol?

    Yes. Paracetamol and gastro-resistant naproxen can be taken together because they work in different ways. This combination often helps when inflammation and general pain are both present. Avoid taking other anti-inflammatory medicines at the same time unless advised.

  • Should I still take gastro-resistant naproxen with food?

    Yes. Although the coating helps protect the stomach, taking the tablets with food or milk gives additional protection and reduces the chance of indigestion. Taking them on an empty stomach may still cause irritation.

  • Can I drink alcohol while using gastro-resistant naproxen?

    Light drinking is usually safe, but alcohol can still irritate the stomach and increase the risk of side effects. People with any history of digestive issues should avoid alcohol altogether while using naproxen.

  • What should I do if gastro-resistant naproxen does not help my pain?

    If your symptoms are not improving, you may need a different medication, dosage adjustment or an alternative treatment depending on the cause of your pain. Adding paracetamol can help for some conditions. A clinician can advise on next steps.

  • Do gastro-resistant tablets reduce the risk of ulcers?

    The coating lowers the chance of irritation, but it does not eliminate ulcer risk, especially for people with previous stomach problems. In higher-risk patients, a clinician may prescribe a stomach-protective medicine alongside naproxen to reduce complications.

  • How long can I use gastro-resistant naproxen for safely?

    Short-term use is typically safe for most adults. Longer courses may be needed for inflammatory conditions, but ongoing monitoring is recommended. Regular checks for kidney function, blood pressure and stomach symptoms may be required if used long term.

  • Can I buy gastro-resistant naproxen online in the UK?

    Yes. It can be supplied from a registered UK pharmacy after a clinical consultation confirms it is safe for you. You will be asked about any stomach conditions, medicines you take and other health risks to ensure the gastro-resistant version is appropriate.