• Contains an antibiotic, antifungal, and corticosteroid to treat multiple causes at once
  • Relieves redness, itching, and irritation while tackling underlying infection
  • Often prescribed for eczema, dermatitis, or fungal infectio

How it works?

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Overview

Trimovate Cream is a powerful triple-action treatment for sore, inflamed, and infected skin. It combines a moderate steroid (clobetasone butyrate) to calm irritation, an antibiotic (oxytetracycline) to clear bacterial infection, and an antifungal (nystatin) to tackle yeast infections.

This makes Trimovate a versatile choice for infected eczema, dermatitis, and stubborn rashes, especially where both bacteria and fungi may be involved.

This medicine requires a secure online consultation with a UK-registered prescriber, and will only be supplied if clinically appropriate.


What is Trimovate 


Trimovate Cream is designed for skin conditions where multiple issues occur at once — inflammation, infection, and yeast overgrowth.

How it works:

  • Clobetasone Butyrate (0.05%) – a moderate-strength steroid that reduces redness, itching, and swelling.
  • Oxytetracycline – an antibiotic that fights bacteria on the skin.
  • Nystatin – an antifungal that clears yeast infections like Candida.


Common uses include:

  • Infected eczema or dermatitis
  • Rashes in moist or sweaty areas (groin, under breasts, armpits)
  • Thrush-related irritation with secondary bacterial involvement
  • Mixed skin infections where both bacteria and fungi are present

Directions

  • Apply a thin layer to the affected area 2–3 times daily, or as directed by your prescriber.
  • Use only on the patches of skin affected.
  • Do not use for longer than 7–10 days without medical review.
  • Wash hands before and after applying.
  • Avoid use on large areas, broken skin, or under dressings unless prescribed.

Side Effects

Like all medicines, Trimovate can cause side effects, although not everyone will experience them.

Common (may affect up to 1 in 10 people, usually mild):

  • Temporary stinging or irritation
  • Mild redness or itching


Less common (may affect up to 1 in 100 people, more likely with prolonged or excessive use):

  • Thinning of the skin
  • Stretch marks
  • Visible blood vessels
  • Worsening of untreated skin infections


Most people tolerate Trimovate well, and side effects (if they do occur) are usually mild. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

  • Do not use if allergic to clobetasone, oxytetracycline, nystatin, or any ingredient.
  • Not suitable for untreated viral or fungal infections (e.g. cold sores, athlete’s foot without bacterial involvement).
  • Avoid prolonged use, especially on delicate areas (face, groin, genitals).
  • Not recommended in pregnancy or breastfeeding unless specifically advised.
  • Use only as directed by your prescriber to prevent resistance or side effects.
Frequently asked questions

  • What is Trimovate Cream and what is it used for?

    Trimovate Cream contains clobetasone butyrate, nystatin and oxytetracycline. It is used to treat inflamed skin that also shows signs of bacterial or fungal infection. It is commonly prescribed for infected eczema, irritated skin folds and mixed-cause rashes needing both antimicrobial and anti-inflammatory treatment.

  • How does Trimovate work?

    Trimovate treats several problems at once. Clobetasone reduces swelling and redness, nystatin targets yeast and oxytetracycline manages susceptible bacteria. This makes it useful for rashes that are inflamed, sore and partly infected.

  • How do I apply Trimovate properly?

    Apply a thin layer of Trimovate to clean, dry skin two or three times a day unless instructed otherwise. Use only on affected areas and avoid airtight dressings unless prescribed. Wash hands after use and avoid contact with the eyes or mouth.

  • When should Trimovate not be used?

    Trimovate should not be used on viral infections such as cold sores, chickenpox, shingles or on untreated fungal infections like athlete’s foot. It is also unsuitable for acne, rosacea or widespread skin thinning.

  • How long can I use Trimovate for?

    Trimovate is usually prescribed for short courses of 7-10 days. Longer use increases the risk of side effects from the steroid and may reduce antibiotic effectiveness. If symptoms persist, speak to a clinician.

  • What side effects can Trimovate cause?

    Common effects of Trimovate include mild burning, stinging or dryness when applied. Longer courses may cause skin thinning, stretch marks or increased hair growth due to the steroid. If irritation worsens or infection spreads, stop using it and seek advice.

  • Can Trimovate be used on the face or groin?

    Trimovate can be used on these areas only if prescribed, because thinner skin absorbs steroids more easily, raising the risk of side effects. Use sparingly and avoid long courses in sensitive areas.

  • Does Trimovate help with infected eczema?

    Yes. Trimovate is often used when eczema becomes inflamed, cracked and infected by bacteria or yeast. The three-part formula helps calm inflammation while treating underlying infection. If eczema infections keep returning, your clinician may review ongoing skin management.

  • Can I use emollients alongside Trimovate?

    Yes. Emollients support healing by restoring the skin barrier. Apply Trimovate first, allow it to absorb and then use emollients between applications. Avoid putting thick emollients directly over the cream.

  • Is Trimovate suitable for fungal infections alone?

    No. While Trimovate contains nystatin, it is not suitable as first-line treatment for simple fungal infections. Conditions like ringworm or athlete’s foot respond better to antifungal-only medicines such as Terbinafine.

  • Can Trimovate be used in pregnancy or breastfeeding?

    Trimovate may be used on small areas for short periods if advised by a clinician. Avoid applying it to the breasts while breastfeeding to prevent transfer to the baby.

  • Can Trimovate help with sore skin folds or under-breast inflammation?

    Yes. It may be prescribed when folds become inflamed, over-moist and show signs of yeast or bacterial involvement. The combination in Trimovate helps calm irritation and reduce microbial load.

  • What should I do if symptoms worsen while using Trimovate?

    Stop using Trimovate cream and seek medical advice if redness spreads, the area becomes painful, pus develops or a fever occurs. This may indicate resistant bacteria or an infection that needs oral treatment.

  • Can Trimovate be used for athlete’s foot or jock itch?

    It is not first choice for these conditions. Dedicated antifungals such as terbinafine or clotrimazole are usually more effective. Trimovate may be considered if inflammation is severe and there is mixed infection.

  • Can I use Trimovate alongside oral antibiotics or antifungals?

    Yes. Sometimes both topical and oral treatments are used together, especially for stubborn or deeper infections. Your clinician will advise whether combination therapy is needed.

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