• Provides reliable, long-lasting relief from reflux and indigestion
  • Helps heal and protect the stomach and oesophagus from acid damage
  • Trusted first-line PPI with decades of safe, proven use

How it works?

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Overview

Heartburn and acid reflux can creep into every part of life — making meals uncomfortable, nights restless, and daily routines frustrating. Omeprazole is one of the UK’s most trusted treatments for reflux and indigestion, working by calming excess stomach acid at its source. By easing burning pain, protecting your oesophagus, and helping your body heal, Omeprazole gives you the freedom to eat, sleep, and live with confidence again.

At SwiftMedi, every request for Omeprazole is carefully reviewed by a UK-registered prescriber through a secure online consultation, with discreet delivery direct to your door.


What is Omeprazole


Omeprazole is a medicine from the group known as proton pump inhibitors (PPIs). It works by blocking the acid-producing pumps in the stomach, which lowers the amount of acid made and helps prevent further irritation to the oesophagus and stomach lining.

It is commonly prescribed for frequent heartburn and acid reflux, gastro-oesophageal reflux disease (GORD), and for the treatment of stomach or duodenal ulcers. Omeprazole is also used as protection against ulcers in patients who need to take NSAIDs long-term.

With decades of safe and effective use, omeprazole is often the first-line choice for reflux and related conditions, providing reliable, long-lasting relief and helping patients return to everyday comfort.

Directions

  • Usual adult dose: 10mg to 40mg once daily, depending on severity and condition.
  • Take in the morning, preferably before food.
  • Swallow capsules whole with water — do not crush or chew.
  • Some patients may need a short course (2–4 weeks), while others may require longer-term treatment for GORD.
  • Always follow the instructions provided by your prescriber.

Side Effects

Like all medicines, omeprazole can cause side effects, although not everyone will experience them. Most are mild and improve as your body adjusts to treatment.

Common (may affect up to 1 in 10 people):

  • Headache – usually mild and short-lived.
  • Stomach pain, diarrhoea, constipation, or nausea – digestive symptoms are the most common effects but are generally mild.
  • Wind (flatulence) – some people may experience bloating or excess gas.


Uncommon (may affect up to 1 in 100 people):

  • Dizziness, tiredness, or sleep disturbances – these may affect alertness; avoid driving if you feel unwell.
  • Dry mouth or changes in taste – usually mild and temporary.
  • Skin rash or itching – typically mild but seek advice if persistent.


Rare but serious (seek urgent medical advice):

  • Severe allergic reaction (anaphylaxis) – symptoms include swelling of the face, lips, tongue, or throat, difficulty breathing, or a sudden rash.
  • Severe abdominal pain or vomiting blood – may indicate stomach bleeding or ulcer complications.
  • Yellowing of the skin or eyes (jaundice) – a possible sign of liver problems.


Most people tolerate omeprazole well, and side effects are usually mild. If you are concerned about any symptoms, or if they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Omeprazole may not be suitable if you:

  • Are allergic to omeprazole, esomeprazole, or other PPIs
  • Have liver disease
  • Are taking medicines such as warfarin, phenytoin, clopidogrel, methotrexate, or HIV treatments
  • Are pregnant or breastfeeding — seek medical advice first
  • Need long-term use — monitoring may be required for vitamin B12, magnesium levels, or bone health
Frequently asked questions

  • What is omeprazole and how does it work?

    Omeprazole is a proton pump inhibitor used for acid reflux, heartburn, indigestion and stomach ulcers. It reduces stomach acid by switching off the acid-producing pumps, giving relief from burning discomfort and regurgitation. It is often a first-choice treatment for ongoing or frequent symptoms.

  • How long does omeprazole take to relieve acid reflux or heartburn?

    Some people notice improvement within a few hours, but full relief usually develops over two to four days as acid levels reduce consistently. Omeprazole is best for regular symptoms rather than immediate relief. Antacids can be used alongside during the first few days if needed.

  • How should I take omeprazole for best results?

    Take omeprazole first thing in the morning with water, at least 30 minutes before eating. Food can reduce absorption, so consistent timing improves effectiveness. Swallow capsules whole. For long-term treatment, using the lowest effective dose is recommended.

  • What side effects can omeprazole cause?

    Common side effects include headache, stomach pain, bloating, nausea and diarrhoea or constipation. Most are mild and settle with continued use. Rare effects include dizziness or low magnesium. If symptoms worsen or persist, review with a clinician.

  • Is omeprazole safe for long-term use?

    Many people take omeprazole long term, but regular reviews are advised. Long-term use may affect magnesium, calcium or vitamin B12 levels in some people. Your clinician will aim to keep you on the lowest effective dose to manage symptoms safely.

  • Who should avoid omeprazole?

    Omeprazole may not be suitable for people with severe liver problems, unexplained weight loss, difficulty swallowing or symptoms of stomach bleeding. Always check safety if you take other regular medicines or have long-standing digestive issues.

  • Can omeprazole interact with other medicines?

    Yes. Omeprazole can interact with medicines such as clopidogrel, warfarin, digoxin, antifungals and some antivirals. It may also affect drugs that rely on stomach acidity for absorption. A consultation ensures it’s safe with your current medicines.

  • Is omeprazole stronger than lansoprazole or esomeprazole?

    All PPIs reduce stomach acid, but their strength varies slightly. Esomeprazole is sometimes considered a little stronger, while omeprazole and lansoprazole offer similar relief for most people. Effectiveness often depends on dose and consistency rather than the specific PPI.

  • Can I take omeprazole at night instead of in the morning?

    It’s usually best taken in the morning, but some people prefer night-time dosing if symptoms are worse overnight. It still needs to be taken on an empty stomach for best absorption. If switching times, keep the new timing consistent each day.

  • Can omeprazole be taken with antacids or alginates like Gaviscon?

    Yes. Antacids or alginates provide fast relief while omeprazole reduces acid long term. Leave a two-hour gap between them to avoid affecting absorption. Many people combine both during flare-ups.

  • Why does acid reflux return after stopping omeprazole?

    Some people experience “acid rebound” when stopping PPIs suddenly. Acid levels may temporarily rise above normal, causing symptoms to flare. Reducing the dose gradually or switching to H2 blockers can help. A clinician can guide a safe step-down plan.

  • Can I take omeprazole as needed rather than daily?

    Yes. Some people use omeprazole intermittently for occasional symptoms, though daily use gives more reliable control. If your symptoms are predictable, “on-demand” dosing may still work but takes longer to kick in than antacids.

  • Does omeprazole help with stomach ulcers or gastritis?

    Yes. By reducing acid, omeprazole helps heal gastric and duodenal ulcers and reduces inflammation from gastritis. Treatment length depends on severity and may range from two to eight weeks. It is often used alongside antibiotics if infection is present.

  • Can I use omeprazole during pregnancy or breastfeeding?

    Omeprazole is often considered safe in pregnancy when symptoms are significant and other treatments haven’t helped. It can also be used while breastfeeding. A clinician will confirm suitability for your situation.

  • What should I do if omeprazole stops working?

    If symptoms return, the dose or timing may need adjusting. A clinician might switch you to another PPI, add an H2 blocker, or investigate triggers such as food, alcohol or late meals. Persistent symptoms should always be assessed.