• Relieves IBS cramps and bloating by relaxing gut muscles
  • Targets symptoms directly without causing drowsiness
  • Well-tolerated for long-term management of recurring flare-ups

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Overview

IBS cramps, bloating, and discomfort can disrupt your day without warning. Colofac Tablets (135mg & 200mg) are the trusted branded form of mebeverine, working directly on the bowel muscles to ease spasms and restore comfort. With Colofac, you can manage flare-ups discreetly and feel more confident getting on with life.
At SwiftMedi, all requests are reviewed by a UK-registered prescriber via secure online consultation, with fast, discreet delivery to your door.


What is Colofac


Colofac contains mebeverine hydrochloride, an antispasmodic medicine that relaxes the smooth muscle of the gut.

It is commonly prescribed for:

  • Irritable Bowel Syndrome (IBS)
  • Chronic irritable colon
  • Spastic constipation
  • Other conditions involving painful gut spasms


By reducing spasms without slowing normal bowel movement, Colofac relieves:

  • Abdominal pain and cramps
  • Bloating and trapped wind
  • Urgency linked to IBS flare-ups

Directions

Colofac 135mg:

  • Usual dose: 1 tablet three times a day
  • Take 20 minutes before meals with water


Colofac MR 200mg (Modified Release)

  • Usual dose: 1 capsule twice a day (morning and evening)
  • Swallow whole with water — do not crush or chew

Side Effects

Like all medicines, Colofac can cause side effects, although not everyone will experience them. Side effects are uncommon and usually mild.

Uncommon (may affect up to 1 in 100 people):

  • Mild skin rash or itching
  • Indigestion or nausea


Rare but serious (seek medical help immediately):

  • Allergic reaction (swelling, rash, difficulty breathing)
  • Severe blistering rash or skin reaction


Most people tolerate Colofac well, and side effects (if they do occur) are rare. If you are concerned about any symptoms, or they do not improve, speak to your doctor, pharmacist, or prescriber.

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet provided with your medicine for full details. If you experience severe or worrying symptoms, seek medical advice straight away. In an emergency, call 999 or go to A&E.

Warnings

Colofac may not be suitable if you:

  • Are under 18 years old
  • Are pregnant or breastfeeding (unless approved by your prescriber)
  • Have lactose intolerance (some formulations may contain lactose)
  • Have had an allergic reaction to mebeverine or similar medicines


Always disclose your medical history and current medicines during your consultation.

FAQ's

Is Colofac the same as Mebeverine?
Yes — Colofac is a branded version of mebeverine hydrochloride.

Which is better, Colofac 135mg or 200mg?
Both contain mebeverine. The 200mg modified-release capsules are taken twice a day, which some people find more convenient.

How quickly does Colofac work?
Relief can start within hours, but regular use may be needed for full effect.

Can I take Colofac long term?
Yes, many people use Colofac safely for long-term IBS management under prescriber guidance.

Does Colofac cure IBS?
No — it manages symptoms like cramps and bloating but does not cure IBS.

Frequently asked questions
  • What is Colofac and how does it work for IBS ?

    Colofac is a branded version of mebeverine that relaxes the bowel muscles to ease gripping pain, cramping and digestive discomfort linked to IBS. It targets spasms directly, helping the gut move more smoothly and reducing sudden flare ups. Many people choose the branded option for consistency and confidence in symptom control.

  • Is Colofac more effective than generic mebeverine?

    Colofac contains the same active ingredient as generic mebeverine, so effectiveness is medically identical. Some people feel branded tablets offer more predictable symptom control, while others choose generics for affordability. Both options work by reducing bowel spasms that trigger IBS pain.

  • How long does Colofac take to relieve IBS pain?

    Colofac often starts easing cramping within a few hours, but full benefit may develop over several days of regular use. Taking it before meals helps prevent digestion-triggered flare ups. Consistent dosing is important during active symptom periods to keep spasms under control.

  • How do I take Colofac safely?

    The usual dose is one tablet twenty minutes before meals, up to three times daily. Swallow tablets whole with water and avoid taking more than recommended. If your symptoms continue despite regular use, speak to a clinician to review alternative IBS treatments or triggers.

  • What side effects can Colofac cause?

    Colofac is usually well tolerated but may occasionally cause nausea, headaches, or mild digestive upset. Serious reactions are uncommon. Seek medical advice if you notice swelling, rash or breathing issues. If side effects persist, a clinician may recommend adjusting your treatment approach.

  • Who should not take Colofac?

    Avoid Colofac if you have severe bowel disease, paralytic ileus, or an allergy to mebeverine. Caution is recommended during pregnancy, breastfeeding, or when taking other gut-acting medicines. If you have unexpected symptoms like weight loss or bleeding, seek advice first.

  • Does Colofac help prevent meal-triggered IBS flare ups?

    Yes. Colofac works particularly well when cramping starts soon after eating. Taking it before meals relaxes bowel muscles in advance, helping reduce spasms during digestion. It can be especially effective for people whose IBS pain follows large or high-fat meals.

  • Can Colofac help with IBS-M (mixed bowel habits)?

    Colofac can help IBS-M by easing muscle spasms that occur alongside alternating constipation and diarrhoea. While it doesn’t change bowel habit directly, reducing sharp cramps often makes flare ups more manageable. Many people use it alongside diet changes tailored to their symptom pattern.

  • Does Colofac reduce bloating or trapped wind?

    Colofac can help reduce bloating if the sensation is caused by spasms or tightening in the bowel. For bloating linked to fermentation or slow movement of gas, adding peppermint oil or adjusting fibre intake may work better. Combining approaches often gives stronger relief.

  • Can I take Colofac with food?

    Colofac works best when taken before meals, especially if eating triggers cramps. You can eat normally while using it, but avoiding very large or high-fat meals may help reduce flare ups. Staying hydrated and eating slowly can also support symptom control.

  • Is Colofac suitable for long-term IBS management?

    Yes. Many people use Colofac long term, especially if their IBS symptoms repeatedly flare with meals or stress. Regular reviews are helpful to ensure the treatment remains effective and to check whether additional approaches, such as diet modification or stress management, might provide extra benefit.

  • Can I use Colofac with probiotics, peppermint oil or dietary changes?

    Yes. Colofac reduces spasms, while probiotics, peppermint oil and fibre adjustments target bloating, gas and digestion. Using them together often supports broader symptom control. A simplified diet may also help during flare periods.

  • What if Colofac makes me feel nauseous?

    Mild nausea can happen, especially when first starting Colofac. Taking the tablet with a small sip of water and eating smaller meals may help. If nausea persists or worsens, speak to a clinician about switching to another antispasmodic or adjusting your IBS plan.

  • Does Colofac help stress-related IBS pain?

    Colofac helps relax the bowel during stress-triggered spasms, but combining it with stress-reduction strategies usually improves overall control. Many people benefit from breathing exercises, sleep routines and identifying stress triggers alongside medication use.

  • What should I do if Colofac stops working?

    If Colofac becomes less effective, review your dosing pattern and consider whether diet, stress or lifestyle changes have shifted. A clinician may suggest switching to Mebeverine generic, Buscopan or alternative therapies. Persistent symptoms should be assessed.

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