• Works in just 15 minutes
  • Proven effective migraine treatment
  • Relieves pain, nausea and sensitivity together

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Overview

Migraines can feel overwhelming, but fast and targeted relief is possible. Zolmitriptan is a trusted treatment designed to stop migraine attacks in their tracks. By directly addressing the brain changes that trigger migraines, it helps ease throbbing pain, nausea, and sensitivity within the hour - so you can regain control, restore comfort, and get back to living your life.


All requests through SwiftMedi are reviewed by a UK-registered prescriber via a secure online consultation, with discreet delivery straight to your door.


What are Zolmitriptan tablets

Zolmitriptan belongs to the triptan family (5-HT1 receptor agonists) and is used for the acute treatment of migraine attacks, with or without aura.

It works by:

  • Narrowing widened blood vessels in the brain
  • Blocking pain signals carried by overactive nerve pathways
  • Relieving migraine symptoms such as pain, nausea, and sensitivity to light/sound

 

Zolmitriptan is available in oral tablets and orodispersible tablets (melt on the tongue), offering flexibility depending on your needs

Directions

  • Take one 2.5mg or 5mg tablet at the first signs of migraine.
  • If the migraine improves but then returns, a second dose may be taken after 2 hours.
  • Do not take more than 10mg in 24 hours.
  • Tablets should be swallowed whole with water.


Not recommended for children under 18. Always follow your prescriber’s guidance.

Side Effects

Like all medicines, Zolmitriptan can cause side effects, although not everyone gets them.

Common (may affect up to 1 in 10 people):

  • Drowsiness or tiredness
  • Dizziness
  • Warm sensation or flushing

 

Less common (may affect up to 1 in 100 people):

  • Tingling or heaviness in the body
  • Dry mouth or indigestion
  • Muscle weakness or aches

 

Rare but serious (seek medical advice immediately):

  • Severe chest pain, pressure or tightness
  • Signs of a severe allergic reaction: swelling of the face, lips, tongue or throat, or difficulty breathing
  • Irregular heartbeat or palpitations

 

Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet that comes with your medicine. If you notice anything unusual or concerning, stop using the medicine and seek medical advice promptly. In an emergency, call 999 or go to A&E.

Warnings

Zolmitriptan may not be suitable if you:

  • Are under 18 or over 65
  • Are pregnant or breastfeeding (unless advised)
  • Have heart disease, uncontrolled high blood pressure, or a history of stroke
  • Are taking other triptans or ergotamine medicines
  • Are taking SSRIs, SNRIs, or MAOIs (antidepressants)
  • Have liver or kidney problems


Always provide your prescriber with your full medical history.

Frequently asked questions
  • What is zolmitriptan and how does it treat migraines?

    Zolmitriptan is a triptan used to treat migraine symptoms by narrowing widened blood vessels and calming overactive pain pathways. It works best when taken early in an attack and can reduce pain, sensitivity to light and nausea. It is commonly used when other migraine tablets have not been effective.

  • How long does zolmitriptan take to work?

    Zolmitriptan usually begins working within 30–60 minutes. Some people find it has a smoother and more consistent effect than older triptans. Taking it as soon as the migraine begins generally improves the overall response and reduces the chance of symptoms returning.

  • How should I take zolmitriptan tablets for best results?

    Take one tablet at the start of your migraine and swallow it with water. If your attack comes with nausea, take it with small sips of fluid. Avoid delaying treatment because early dosing helps the tablet absorb better and reduces the risk of a prolonged attack. Follow any maximum dose limits set by your prescriber.

  • What side effects can zolmitriptan cause?

    Common side effects include tingling, warm sensations, dizziness or tiredness. Some people notice pressure in the neck or jaw during treatment, which usually settles quickly. Serious symptoms such as chest pain or breathlessness require urgent medical help. Speak to a clinician if side effects become frequent or troublesome.

  • Who should not take zolmitriptan?

    Zolmitriptan is unsuitable for people with heart disease, previous stroke, uncontrolled high blood pressure or certain vascular conditions. It should also be avoided with some antidepressants and migraine preventers. A clinician will check your medical history before prescribing it.

  • Can I take a second dose of zolmitriptan if the migraine returns?

    Yes. If your migraine symptoms return after initial relief, a second tablet may be taken after the recommended interval as long as you stay within the daily maximum dose. Many people find this helpful for attacks that flare again several hours later.

  • Is zolmitriptan as effective as sumatriptan or rizatriptan?

    Yes. Zolmitriptan is considered equally effective for many people and sometimes preferred for a smoother onset or more predictable relief. Some people respond better to one triptan than another, so trying an alternative can be useful if a previous option has not worked well.

  • Does zolmitriptan work for migraines that don’t respond to sumatriptan?

    Sometimes yes. Zolmitriptan has slightly different absorption and receptor activity, so it can work for people who had limited benefit from sumatriptan. Switching between triptans is common when finding the right match for your migraine pattern. A clinician can help decide which one suits you best.

  • Can I use zolmitriptan for migraines with aura?

    Yes. Zolmitriptan can be used for migraines with or without aura, but it should be taken after the aura finishes and the headache phase begins. Taking it too early during the aura usually reduces effectiveness, so timing is important for good results.

  • Why does zolmitriptan sometimes cause tingling or warm sensations?

    Tingling or warm sensations are common effects linked to how triptans work on pain pathways and blood vessels. These feelings are usually mild and fade quickly as the tablet is absorbed. If the sensations are intense or worrying, speak to a clinician to review your treatment.

  • Is zolmitriptan suitable if I get frequent morning migraines?

    Yes. Morning migraines often respond well to zolmitriptan because it has steady absorption and works reliably on an empty stomach. Taking it as soon as symptoms begin usually prevents the attack progressing and reduces the need for additional pain relief.

  • Can zolmitriptan help if my migraines come with neck pain or pressure?

    Yes. Neck tightness or pressure is a common part of migraine attacks rather than a separate problem. Zolmitriptan can ease this by settling the underlying migraine pathways. If symptoms feel unusual or one-sided, speak to a clinician for review.

  • How long can I keep zolmitriptan tablets at home for future attacks?

    Zolmitriptan tablets normally have a long shelf life, so they can be kept for future attacks as long as they stay within the expiry date and are stored correctly. Many people keep a pack in different locations so they can treat migraines early.

  • Can I use zolmitriptan alongside anti-sickness tablets?

    Yes. Medicines such as metoclopramide or prochlorperazine can be safely used with zolmitriptan to help manage nausea. This often improves absorption and overall symptom control. Avoid codeine-based medicines because they increase the risk of medication-overuse headaches.

  • What should I do if zolmitriptan only gives partial relief?

    If pain improves but doesn’t fully settle, a second dose may be possible after the advised interval. If this is a regular issue, switching to a different triptan or exploring preventer treatment can give better long-term control.