• Provides fast, targeted relief from thrush
  • Convenient single-dose treatment trusted worldwide
  • Works directly at the site of infection

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Overview

Clotrimazole 500mg Pessary is a single-dose vaginal treatment for thrush that works just like Canesten — but at a lower cost.
It delivers the same trusted antifungal medicine directly to the site of infection, providing fast and effective relief from itching, soreness, and discharge.


What is Clotrimazole 500mg Pessary


Thrush is caused by an overgrowth of the yeast Candida albicans, which leads to vaginal itching, irritation, thick discharge, and swelling. Clotrimazole 500mg Pessary works by stopping the yeast from multiplying, allowing your body to restore its natural balance.

Inserted directly into the vagina at bedtime, the pessary provides targeted treatment overnight, making it a discreet and convenient alternative to oral capsules.

As the generic version of Canesten 500mg Pessary, it contains the exact same active ingredient (clotrimazole 500mg), giving you the same effectiveness - at a more affordable price.

Directions

  • Insert one 500mg pessary deep into the vagina at bedtime using the applicator provided.
  • Wash hands before and after use.
  • Do not use tampons during treatment.
  • Symptoms usually improve within 2–3 days, with full relief in up to 7 days.

Side Effects

Most women tolerate clotrimazole pessaries well, but side effects may occur.

Common (may affect up to 1 in 10 people):

  • Mild burning or stinging after insertion
  • Vaginal discomfort


Less common (may affect up to 1 in 100 people):

  • Itching or redness around the vulva
  • Skin rash


Rare but serious (seek urgent medical advice):

  • Severe allergic reaction (swelling, rash, difficulty breathing)


Disclaimer: This is not a complete list of side effects. Always read the patient information leaflet that comes with your medicine for full details. If you notice anything unusual or concerning, stop using the treatment and seek medical advice promptly. In an emergency, call 999 or go to A&E.

Warnings

  • Not suitable if allergic to clotrimazole or other antifungal medicines.
  • Avoid use in pregnancy unless advised by your prescriber (insert without applicator if used).
  • Creams and pessaries may weaken latex condoms and diaphragms — use alternative contraception during treatment.
  • Do not use during menstruation.
Frequently asked questions
  • What is the Clotrimazole 500mg pessary used for?

    The Clotrimazole 500mg pessary is a single-dose internal treatment for uncomplicated vaginal thrush. It works by delivering clotrimazole directly into the vagina where it kills the yeast causing infection. It is suitable for women who have previously been diagnosed with thrush and recognise their symptoms.

  • How do I use the Clotrimazole 500mg pessary?

    Insert the pessary deep into the vagina before bedtime using the applicator provided. This gives the medication time to dissolve fully overnight. Avoid sexual activity during treatment and wear a panty liner if needed, as mild discharge is normal as the pessary melts.

  • How quickly does the Clotrimazole 500mg pessary work?

    Many women notice symptom relief within 24 hours, with full improvement typically within three days. The single high-dose pessary is designed to give rapid, effective internal treatment. If symptoms persist for more than seven days, you may need reassessment.

  • Can I use the pessary alongside an external cream for itching?

    Yes. The pessary treats the internal infection, but it does not relieve external itching or soreness. Many women choose to use clotrimazole 2% External Cream alongside it for faster comfort. This combination is often recommended for complete symptom control.

  • Who should not use the Clotrimazole 500mg pessary?

    Do not use it if you are pregnant, allergic to clotrimazole, have irregular bleeding, fever, pelvic pain, unusual discharge or this is your first suspected episode of thrush.Medical review is recommended if you have recurrent infections or underlying health concerns.

  • What side effects can occur with the pessary?

    Mild burning, stinging or increased discharge are common and temporary as the pessary dissolves. Some women may experience abdominal discomfort or local irritation. Serious reactions are rare, but stop use if symptoms worsen or allergic signs develop.

  • Do I need more than one dose of the 500mg pessary?

    Most women only require one pessary, but a second dose may be needed if symptoms are slow to improve or if the infection is more persistent. If frequent treatment is required, consider an alternative such as fluconazole or further medical assessment.

  • Will the Clotrimazole 500mg pessary leak out overnight?

    Yes. As the pessary melts, it releases medication which can cause a white, chalky discharge. This is completely normal and does not mean the treatment is ineffective. Wearing a panty liner overnight can make the experience more comfortable.

  • Can I use the pessary during my period?

    It is better to wait until your period finishes. Menstrual flow can wash the medication out, making treatment less effective. If symptoms are severe, speak with a clinician about whether to treat immediately or wait for menstruation to end.

  • Does the pessary affect condoms?

    Yes. Clotrimazole may weaken latex condoms and diaphragms for several days after use. To avoid contraceptive failure, use non-latex condoms or alternative contraception until treatment is fully completed and irritation has settled.

  • Can I use the pessary if I’m unsure whether my symptoms are thrush?

    If you are uncertain or this is your first episode, seek assessment before using the pessary. Conditions like bacterial vaginosis, dermatitis or STIs can mimic thrush, and using antifungals will not help if the diagnosis is incorrect.

  • Can I insert the pessary without the applicator?

    Yes. Some women prefer to insert the pessary with a finger rather than the applicator, especially if they find applicators uncomfortable. Ensure hands are clean and push the pessary high into the vagina for best effectiveness.

  • Can the pessary cause discomfort if inserted too low?

    Yes. If not inserted high enough, the pessary may dissolve closer to the opening, causing leakage, irritation or incomplete treatment. Re-reading the instructions and using the applicator can prevent this issue.

  • Does the pessary help with external itching as well?

    The pessary mainly treats the internal infection and does not always relieve external itching. If external symptoms are significant, pairing it with a clotrimazole external cream gives faster relief and a more complete recovery.

  • What if symptoms come back soon after using the pessary?

    Recurrence may indicate reinfection, incomplete treatment, antibiotic use, or another condition mimicking thrush. A clinician may recommend a repeat pessary, fluconazole, or a longer treatment plan if infections are frequent.

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